BIOS 6450 - DESIGN AND ANALYSIS OF EXPRESSION STUDIES

[3 Credits]

Three hours of lecture per week. Introduction to DNA, RNA, protein and gene expression; statistical methods; microarray technology; data visualization and quality control; variability in microarray data; specific and non-specific hybridization– background correction; normalization and transformation; gene expression summarization; missing value problems; detection of differentially expressed genes; design of microarray experiments. Prerequisite: BIOS 6202.